اپی ژنتیک در پیری و بیماری

منابع:

1. Shioi T, Inuzuka Y (2012) Aging as a substrate of heart failure. J

Cardiol 60:423–428

2. Kennedy BK, Berger SL, Brunet A et al (2014) Geroscience: linking

aging to chronic disease. Cell 159:709–713

3. Flavahan WA, Gaskell E, Bernstein BE (2017) Epigenetic plasticity

and the hallmarks of cancer. Science 357:eaal2380

4. Ou HL, Schumacher B (2018) DNA damage responses and p53

in the aging process. Blood 131:488–495

5. Papait R, Serio S, Pagiatakis C et al (2017) Histone methyltransferase

G9a is required for cardiomyocyte homeostasis and

hypertrophy. Circulation 136:1233–1246

6. Papait R, Cattaneo P, Kunderfranco P et al (2013) Genome-wide

analysis of histone marks identifying an epigenetic signature of

promoters and enhancers underlying cardiac hypertrophy. Proc

Natl Acad Sci U S A 110:20164–20169

7. Papait R, Corrado N, Rusconi F et al (2015) It’s time for An epigenomics

roadmap of heart failure. Curr Genomics 16:237–244

8. Papait R, Kunderfranco P, Stirparo GG et al (2013) Long noncoding

RNA: a new player of heart failure? J Cardiovasc Transl

Res 6:876–883

9. Sun X, Hota SK, Zhou YQ et al (2018) Cardiac-enriched BAF

chromatin-remodeling complex subunit Baf60c regulates gene

expression programs essential for heart development and function.

Biol Open 7:bio029512

10. Okano M, Bell DW, Haber DA et al (1999) DNA methyltransferases

Dnmt3a and Dnmt3b are essential for de novo methylation

and mammalian development. Cell 99:247–257

11. Greco CM, Kunderfranco P, Rubino M et al (2016) DNA

hydroxymethylation controls cardiomyocyte gene expression

in development and hypertrophy. Nat Commun 7:12418

12. Salamon I, Jotti GS, Condorelli G (2018) The long noncoding

RNA landscape in cardiovascular disease: a brief update. Curr

Opin Cardiol 33:282–289

13. Cao Q, Guo Z, Yan Y et al (2019) Exosomal long noncoding

RNAs in aging and age-related diseases. IUBMB Life

71:1846–1856

14. Naylor RM, Baker DJ, van Deursen JM (2013) Senescent cells:

a novel therapeutic target for aging and age-related diseases.

Clin Pharmacol Ther 93:105–116

15. Sartor MA, Dolinoy DC, Jones TR et al (2011) Genome-wide

methylation and expression differences in HPV(+) and HPV(–)

squamous cell carcinoma cell lines are consistent with divergent

mechanisms of carcinogenesis. Epigenetics 6:777–787

16. Zheng Y, Joyce BT, Liu L et al (2017) Prediction of genomewide

DNA methylation in repetitive elements. Nucleic acids Res

45:8697–8711

17. Di Croce L, Raker VA, Corsaro M et al (2002) Methyltransferase

recruitment and DNA hypermethylation of target promoters by

an oncogenic transcription factor. Science 295:1079–1082

18. Wang GG, Allis CD, Chi P (2007) Chromatin remodeling and

cancer, Part I: covalent histone modifications. Trends Mol Med

13:363–372

19. Varambally S, Dhanasekaran SM, Zhou M et al (2002) The

polycomb group protein EZH2 is involved in progression of

prostate cancer. Nature 419:624–629

20. Kleer CG, Cao Q, Varambally S et al (2003) EZH2 is a marker

of aggressive breast cancer and promotes neoplastic transformation

of breast epithelial cells. Proc Natl Acad Sci U S A

100:11606–11611

21. Suva ML, Riggi N, Janiszewska M et al (2009) EZH2 is essential

for glioblastoma cancer stem cell maintenance. Cancer Res

69:9211–9218

22. Liu G, Bollig-Fischer A, Kreike B et al (2009) Genomic amplification

and oncogenic properties of the GASC1 histone demethylase

gene in breast cancer. Oncogene 28:4491–4500

23. Yang ZQ, Imoto I, Fukuda Y et al (2000) Identification of

a novel gene, GASC1, within an amplicon at 9p23-24 frequently

detected in esophageal cancer cell lines. Cancer Res

60:4735–4739

24. Virani S, Colacino JA, Kim JH et al (2012) Cancer epigenetics:

a brief review. ILAR J 53:359–369

25. Chen J, Luo Q, Yuan Y et al (2010) Pygo2 associates with

MLL2 histone methyltransferase and GCN5 histone acetyltransferase

complexes to augment Wnt target gene expression

and breast cancer stem-like cell expansion. Mol Cell Biol

30:5621–5635

26. Yang XJ, Ullah M (2007) MOZ and MORF, two large MYSTic

HATs in normal and cancer stem cells. Oncogene 26:5408–5419

27. Tillinghast GW, Partee J, Albert P et al (2003) Analysis of

genetic stability at the EP300 and CREBBP loci in a panel of

cancer cell lines. Genes Chromosomes Cancer 37:121–131

28. Glozak MA, Sengupta N, Zhang X et al (2005) Acetylation and

deacetylation of non-histone proteins. Gene 363:15–23

29. Morris BJ, Willcox BJ, Donlon TA (2019) Genetic and epigenetic

regulation of human aging and longevity. Biochim Biophys

Acta Mol Basis Dis 1865:1718–1744

30. Nakano K, Whitaker JW, Boyle DL et al (2013) DNA methylome

signature in rheumatoid arthritis. Ann Rheum Dis

72:110–117

31. Bollati V, Schwartz J, Wright R et al (2009) Decline in genomic

DNA methylation through aging in a cohort of elderly subjects.

Mech Ageing Dev 130:234–239

32. Ben-Avraham D, Muzumdar RH, Atzmon G (2012) Epigenetic

genome-wide association methylation in aging and longevity.

Epigenomics 4:503–509

33. Day K, Waite LL, Thalacker-Mercer A et al (2013) Differential

DNA methylation with age displays both common and dynamic

features across human tissues that are influenced by CpG landscape.

Genome Biol 14:R102

34. Jones MJ, Goodman SJ, Kobor MS (2015) DNA methylation

and healthy human aging. Aging Cell 14:924–932

35. Cole JJ, Robertson NA, Rather MI et al (2017) Diverse interventions

that extend mouse lifespan suppress shared age-associated

epigenetic changes at critical gene regulatory regions. Genome

Biol 18:58

36. Gomez-Verjan JC, Vazquez-Martinez ER, Rivero-Segura NA

et al (2018) The RNA world of human ageing. Hum Genet

137:865–879

37. Sun Z, Yang S, Zhou Q et al (2018) Emerging role of exosomederived

long non-coding RNAs in tumor microenvironment.

Mol Cancer 17:82

38. Gensous N, Bacalini MG, Pirazzini C et al (2017) The epigenetic

landscape of age-related diseases: the geroscience perspective.

Biogerontology 18:549–559

39. Rodgers JL, Jones J, Bolleddu SI et al (2019) Cardiovascular risks

associated with gender and aging. J Cardiovasc Dev Dis 6:19

40. Yazdanyar A, Newman AB (2009) The burden of cardiovascular

disease in the elderly: morbidity, mortality, and costs. Clin Geriatr

Med 25:563–577

41. Steenman M, Lande G (2017) Cardiac aging and heart disease in

humans. Biophys Rev 9:131–137

42. Curtis AB, Karki R, Hattoum A et al (2018) Arrhythmias in

patients ≥ 80 years of age: pathophysiology, management, and

outcomes. J Am Coll Cardiol 71:2041–2057

43. Martos R, Baugh J, Ledwidge M et al (2007) Diastolic heart failure:

evidence of increased myocardial collagen turnover linked to

diastolic dysfunction. Circulation 115:888–895

44. Yang Z, Jiang S, Shang J et al (2019) LncRNA: shedding light on

mechanisms and opportunities in fibrosis and aging. Ageing Res

Rev 52:17–31

45. Martin-Fernandez B, Gredilla R (2016) Mitochondria and oxidative

stress in heart aging. Age (Dordr) 38:225–238

46. Nakou ES, Parthenakis FI, Kallergis EM et al (2016) Healthy

aging and myocardium: a complicated process with various effects

in cardiac structure and physiology. Int J Cardiol 209:167–175

47. Carew TE (1989) Role of biologically modified low-density lipoprotein

in atherosclerosis. Am J Cardiol 64:18G–22G

48. Xie W, Santulli G, Reiken SR et al (2015) Mitochondrial oxidative

stress promotes atrial fibrillation. Sci Rep 5:11427

49. Gentilini D, Garagnani P, Pisoni S et al (2015) Stochastic epigenetic

mutations (DNA methylation) increase exponentially in

human aging and correlate with X chromosome inactivation skewing

in females. Aging (Albany NY) 7:568–578

50. Zhang W, Song M, Qu J et al (2018) Epigenetic modifications in

cardiovascular aging and diseases. Circ Res 123:773–786

51. Lind L, Ingelsson E, Sundstrom J et al (2018) Methylation-based

estimated biological age and cardiovascular disease. Eur J Clin

Invest 48:e12872

52. Irvin MR, Zhi D, Joehanes R et al (2014) Epigenome-wide association

study of fasting blood lipids in the genetics of lipid-lowering

drugs and diet network study. Circulation 130:565–572

53. Guay SP, Brisson D, Munger J et al (2012) ABCA1 gene promoter

DNA methylation is associated with HDL particle profile and coronary

artery disease in familial hypercholesterolemia. Epigenetics

7:464–472

54. Han P, Hang CT, Yang J et al (2011) Chromatin remodeling in cardiovascular

development and physiology. Circ Res 108:378–396

55. Pagiatakis C, Sun D, Tobin SW et al (2017) TGFbeta-TAZ/SRF

signalling regulates vascular smooth muscle cell differentiation.

FEBS J 284:1644–1656

56. Post WS, Goldschmidt-Clermont PJ, Wilhide CC et al (1999)

Methylation of the estrogen receptor gene is associated with aging

and atherosclerosis in the cardiovascular system. Cardiovasc Res

43:985–991

57. Connelly JJ, Cherepanova OA, Doss JF et al (2013) Epigenetic

regulation of COL15A1 in smooth muscle cell replicative aging

and atherosclerosis. Hum Mol Genet 22:5107–5120

58. Liang H, Zhang C, Ban T et al (2012) A novel reciprocal loop

between microRNA-21 and TGFbetaRIII is involved in cardiac

fibrosis. Int J Biochem Cell Biol 44:2152–2160

59. Thienpont B, Aronsen JM, Robinson EL et al (2017) The H3K9

dimethyltransferases EHMT1/2 protect against pathological cardiac

hypertrophy. J Clin Invest 127:335–348

60. Haberland M, Montgomery RL, Olson EN (2009) The many roles

of histone deacetylases in development and physiology: implications

for disease and therapy. Nat Rev Genet 10:32–42

61. Montgomery RL, Davis CA, Potthoff MJ et al (2007) Histone

deacetylases 1 and 2 redundantly regulate cardiac morphogenesis,

growth, and contractility. Genes Dev 21:1790–1802

62. Vieira JM, Howard S, Villa Del Campo C et al (2017) BRG1-SWI/

SNF-dependent regulation of the Wt1 transcriptional landscape

mediates epicardial activity during heart development and disease.

Nat Commun 8:16034

63. Zhou XL, Xu H, Liu ZB et al (2018) miR-21 promotes cardiac

fibroblast-to-myofibroblast transformation and myocardial fibrosis

by targeting Jagged1. J Cell Mol Med 22:3816–3824

64. Jazbutyte V, Fiedler J, Kneitz S et al (2013) MicroRNA-22

increases senescence and activates cardiac fibroblasts in the aging

heart. Age (Dordr) 35:747–762

65. Boon RA, Iekushi K, Lechner S et al (2013) MicroRNA-34a regulates

cardiac ageing and function. Nature 495:107–110

66. van Almen GC, Verhesen W, van Leeuwen RE et al (2011) Micro-

RNA-18 and microRNA-19 regulate CTGF and TSP-1 expression

in age-related heart failure. Aging Cell 10:769–779

67. Pagiatakis C, Condorelli G (2019) The RNA methylome blackboard.

Circulation 139:546–548

68. Dorn LE, Lasman L, Chen J et al (2019) The N(6)-methyladenosine

mRNA methylase METTL3 controls cardiac homeostasis

and hypertrophy. Circulation 139:533–545

[1] heart failure

[2][2] ATP-dependent chromatin- remodeling complexes

[3] DNA methyltransferase

[4] enhancer

[5] ubiquitylation

[6] sumoylation

[7] noncoding RNAs

[8] PIWI-interacting RNAs

[9] small interfering RNAs

[10] untranslated region

[11] long interspersed element-1

[12] enhancer of zeste homologue 2

[13] histone acetylases

[14] histone deacetylases

[15] long terminal repeat

[16] short interspersed nuclear element

[17] metastasis- related lung adenocarcinoma transcript 1

[18] HOX transcript antisense RNA

[19] Cardiovascular disease

[20]atherosclerosis

[21] stroke

[22] myocardial infarction